Research interests
The cardiovascular state of animals is remarkably dependent on the environment.
Foraging of food, consumption of food, presence of predators, procuring a
mate, ambient temperature, and general activity are just a few examples of
external stimuli that have a substantial impact on homeostasis of the cardiovascular
system. Research in the Swoap lab examines the underlying mechanisms for cardiovascular
adaptations to both changes in ambient temperature and lack of food availability.
Our approach is an integrative one; combining molecular biology, thermal physiology,
and cardiovascular physiology. Body temperature, blood pressure, and heart
rate measurements are made in genetically modified animals using a telemetry-based
system. This allows for accurate physiological measurements in animals that
are conscious, unrestrained, and freely moving. The use of mice with known
germline mutations allows us to directly test hypotheses that relate caloric
intake, ambient temperature, and metabolism with cardiovascular function.
Publications
- J.R. Shinkle, Steven J. Swoap, P. Simon, R.L. Jones. The cell-wall
free space of Cucumis hypocotyls contains NAD and blue-light regulated peroxidase
activity, Plant Physiol., 98:1336-1341, 1992.
- Steven J. Swoap, S.K. Sooudi, and J.R. Shinkle. Uncorrelated changes
in the distribution of stem elongation, tissue extensibility and cell wall
peroxidase activity alonghypocotyl axes of Cucumis seedlings exhibiting
different patterns of growth, Plant Physiol. Biochem., 31(3): 361-368,
1993.
- Steven J. Swoap, T. Johnson, A. Bennett, R. Josephson. Temperature,
muscle power output, and limitations on burst locomotor performance of the
lizard Dipsosaurus dorsalis, J. Exp. Biol., 174:185-197, 1993. Abstract
and PDF here
- T. Johnson, Steven J. Swoap, A. Bennett, R. Josephson. Body size,
muscle power output, and limitations on burst locomotor performance of the
lizard Dipsosaurus dorsalis, J. Exp. Biol., 174:199-213, 1993. Abstract
and PDF here
- V.J. Caiozzo, Steven J. Swoap, M. Tao, D. Menzel, and K.M. Baldwin.
Single fiber analyses of type IIa myosin heavy chain distribution in hyper-
and hypothyroid soleus, Amer. J. Physiol., 265:C842-C849, 1993. Abstract
and PDF here
- Steven J. Swoap, F. Haddad, P. Bodell, and K.M. Baldwin. Effect
of chronic energy deprivation on cardiac thyroid receptor and myosin isoform
expression, Amer. J. Physiol. 266: E254-E260, 1994. Abstract
and PDF here
- Steven J. Swoap, F. Haddad, V.J. Caiozzo, S. McCue, and K.M. Baldwin.
Interaction of thyroid hormone and functional overload on skeletal muscle
isomyosin expression, J. Appl. Physiol.,77(2): 621-629, 1994. Abstract
and PDF here
- Steven J. Swoap, P. Bodell, and K.M. Baldwin. Interaction of hypertension
and caloric restriction on cardiac mass and isomyosin expression, Amer.
J. Physiol., 268: R33-R39, 1995. Abstract
and PDF here
- Steven J. Swoap, F. Haddad, P. Bodell, and K.M. Baldwin. Control
of β myosin heavy chain expression in systemic hypertension and caloric
restriction in the rat heart, Amer. J. Physiol., 269: C1025-C1033,
1995. Abstract
and PDF here
- Steven J. Swoap, C. Gastellum, P. Bodell, and K.M. Baldwin.
Immunolocalization of rat cardiac β myosin heavy chain protein expression
in hypertension and caloric restriction, Amer. J. Physiol., 269:
C1034-1041, 1995. Abstract
and PDF here
- Steven J. Swoap, V.J. Caiozzo, and K.M. Baldwin. Optimal shortening
velocities for in situ power production of rat soleus and plantaris muscles,
Amer. J. Physiol., 273: C1057-C1063, 1997. Abstract
and PDF here
- Schultz, R., Steven J. Swoap, L. McDaniel, B. Zhang, E. Koon, D.
Garry,K. Li, and R.S. Williams. Differential expression of mitochondrial
DNA replication factors in mammalian tissues. J. Biol. Chem. 273(6): 3447-3451,
1998. Abstract
and full text here
- Steven J. Swoap In vivo analysis of the myosin heavy chain IIB
promoter region. Amer. J. Physiol., 274(43): C681-C687, 1998. Abstract
and full text here
- Kell, R., H.Pierce, and Steven J. Swoap PGAM-M expression
is regulated pre-translationally in hindlimb muscles and under altered loading
conditions. J. Appl. Phsyiol. 86:236-242, 1999. Abstract
and full text here
- Wheeler, M.W., E.C. Snyder, M. Patterson, and Steven
J. Swoap. An E-box within the MHC IIB gene is bound by MyoD and is required
for gene expression in fast muscle. Amer. J. Physiol. 276:C1069-C1078, 1999.
Abstract
and full text here
- Steven J. Swoap, E.J. Stevenson, R.B. Hunter, H. Mitchell-Felton,
N.V. Kansagra, J.M. Lang, K.A. Esser, and S.C. Kandarian. The calcineurin-NFAT
pathway and muscle fiber-type gene expression. Amer. J. Physiology: 279(4):C915-C924,
2000. Abstract
and full text here
- D.J. Seward, J.C. Haney, M.A. Rudnicki, and Steven J.
Swoap. The bHLH transcription factor MyoD is required for the appropriate
regulation of myosin heavy chain IIB expression. Amer. J. Physiology: 280(2):C408-C413,
2001. Abstract
and full text here
- Steven J. Swoap. Altered leptin signaling is sufficient, but not
required, for the hypotension associated with caloric restriction. Amer.
J. Physiology: 281(6): H2473-H2479, 2001. Abstract
and full text here
- Staib, J., Steven J. Swoap, and S. Powers. Diaphragm Contractile
Dysfunction in MyoD Gene Inactivated Mice. Amer. J. Physiology.: 283: R583-R590,
2002. Abstract
and full text here
- Steven J. Swoap, and J.M. Overton. Leptin and Blood Pressure. In
"Nutrition and Heart Disease: Causation and Prevention." CRC press, 105-118,
2004.
- Steven J. Swoap, D. Weinshenker, R.D. Palmiter, and G. Garber.
Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have
abnormal responses to dieting and stress. Amer. J. Physiology: Regul Integr
Comp Physiol 286(1): 108-113, 2004. Abstract
and full text here
- Steven J. Swoap, J.M. Overton, and G. Garber. Effect of
ambient temperature on cardiovascular parameters in rats and mice: a comparative
approach. Am J Physiol Regul Integr Comp Physiol. 287(2):R391-6, 2004. Abstract
and full text here
- Hunt, L.M., E.W. Hogeland, M.K. Henry, and Steven
J. Swoap. Hypotension and bradycardia during caloric restriction in
mice are independent of salt balance and do not require the ANP receptor.
Amer. J. Physiol.: Heart. 287(4): H1446-51, 2004.Abstract
and full text here
- Acharyya, S., K.J. Ladner, L. L. Nelsen, J. Damrauer, P.J. Reiser,
Steven J. Swoap, and D.C. Guttridge. Cancer Cachexia is Regulated
by Selective Targeting of Skeletal Muscle Gene Products. J. Clin. Invest.114(3):370-8,
2004. Abstract
and full text here
- Wisløff, U., S. M. Najjar, Ø. Ellingsen, P. M., Steven
J. Swoap, Q. Al-Share, M. Fernström, K. Rezaei, S. J. Lee,
L.G. Koch, and S.L. Britton. Cardiovascular Risk Factors Emerge from Artificial
Selection for Low Aerobic Capacity in Rats. Science 307: 418-420, 2005.Article
and full text here
- M.M. Messina, S.A. Evans, Steven J. Swoap, and J.M. Overton.
Perinatal MSG treatment attenuates fasting-induced bradycardia and metabolic
suppression. Physiology and Behavior, Oct 15; 86(3):324-30, 2005.Article
and full text here
- Steven J. Swoap, M.J. Gutilla, L.C. Liles, Ross.O.
Smith, and D. Weinshenker. The Full Expression of Fasting-Induced Torpor
Requires beta3 Adrenergic Receptor Signaling. Journal of Neuroscience, 26:
241-245, 2006.Article
and full text here
- Knight, W.D., Steven J. Swoap, A. Parsons, and J.M. Overton.
Central TRH infusion opposes cardiovascular and metabolic suppression during
caloric restriction. Neuroendocrinology, 83(2):69-76, 2006.Article
and full text here
- Gluck, Elizabeth F., Natalie.Stephens, and Steven J. Swoap.
Ghrelin modulates torpor in mice through the Neuropeptide Y signaling pathway.
American Journal of Physiology: Regulatory and Integrative, 291 R1303-R1309,
2006.Abstract
and full text here
- Sowden, Gillian L., D.J. Drucker, D. Weinshenker, and Steven
J. Swoap. Oxyntomodulin increases intrinsic heart rate in mice
independent of the glucagon-like peptide-1 receptor. American
Journal of Physiology: Regulatory and Integrative 292: R962-R970, 2006. Abstract
and full text here
- Swoap, Steven J., Meaghan Rathvon, Margaret Jean Gutilla. AMP does not induce torpor. American Journal of Physiology: Regulatory and Integrative 293: R468–R473, 2007. Abstract
and full text here
Undergraduate authors are underlined
